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Renal dosage Adjustments. Gout Flares: Mild (CrCl 50 to 80 mL/min) to moderate (CrCl 30 to 50 mL/min) renal impairment: No dosage adjustment required, but patients should be monitored closely for adverse effects. Severe (CrCl less than 30 mL/min) renal impairment: No dose adjustment required, but a treatment course should not be repeated more than once every 2 weeks. For patients requiring repeated courses, consideration should be given to alternate therapy.
Colchicine (Colcrys) Nervous system side effects have rarely included myopathy, seizures, mental status changes, and neuropathy in patients with impaired renal function, and are sometimes reversible with drug discontinuation. Neuromyopathy occurrence has been reported with or without elevated muscle enzymes.
Colchicine Musculoskeletal side effects have been reported the most frequently. These have included myopathy, manifested as weakness, neuropathy, and paralysis.
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And here are some feedbacks about Colchicine (Colcrys) pills from some patients:
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I thought gout so I talked to the health care professional again and she looked at it and said possible gout and Rx'ed me with Colchicine (Colcrys) for 5 days. AFTER 2 DAYS I WAS PAIN FREE!! NO PAIN IN MY FEET, SHOULDERS, ELBOWS, KNEES, HANDS, MUSCLES. ANYWHERE. I COULD RUN UP AND DOUM THE STEPS. This was a miricle to me. I have been pain free up till about 2 wks. ago. I am breaking down and giong to have the uric acid blood test. If it is gout then she will Rx allipurinol(sp)? If I dont have gout then I dont know what I do have but Colchicine was my miracle drug.
I have been taking this drug for 2 years now and without it my joints just cease right up. To begin with I felt sick but now I have no side effects
I have been suffering from gout for past 10 years. One instance the pain was so bad I had to call the on call physician. I was diagnosed with gout. I was prescribed Colchicine for the pain. The pain stopped and the swelling decreased. I now take the medication daily and have no problems. I have no complains since I have been on this medication. I'll deal with the side effects of the medication than the severe pain from the gout which is unbearable.
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And here we have more information about Colchicine (Colcrys) pills should be said:
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Colchicine affects the way the body responds to uric acid crystals, which reduces swelling and pain. Generic forms of Colchicine (Colcrys) have been used to treat or prevent attacks of gout, or to treat symptoms of Behcets syndrome (such as swelling, redness, warmth, and pain).
Usual Adult dose for Aphthous Stomatitis - Recurrent - 0.5 to 0.6 mg orally daily. The dose may be titrated upward while the patient is observed for signs of toxicity.
Liver dose Adjustments. Familial Mediterranean Fever: Mild to moderate hepatic impairment: No dose adjustment required, but patients should be monitored closely for adverse effects. dosage reduction may be necessary. Severe hepatic impairment: dose reduction should be considered. In patients with hepatic impairment who are taking protease inhibitors for the treatment of HIV-1 infection, the FDA has recommended against the coadministration of Colchicine (Colcrys).
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And of course a few more opinions about Colchicine tabs from different people:
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I have taken Colchicine off and on during flares, and it seems that it has helped , but it sure makes intestinal problems. I don't want to go out anywhere while taking this medication.
Not only has this drug used on a daily basis eliminated all experiences with gout, I had a fairly bad case of psoriasis on my hands. With the use of Colchicine (Colcrys) my hands completely cleared. Just to make sure that I was not experiencing some new and temporary reaction that led to this psoratic relief, I discontinued the use of the colchincine. The psoriasis in my hand return almost immediately. Upon returning to the use of Colchicine, my hands cleared up once again. Every healthcare professional I have talked to dismisses this because they say that gout and psoriasis are not related. Thats fine, but the bottom line is that this drug suppresses both my gout and psoriasis.
I have FMF and have been on Colchicine for over 4 years now and its a miracle pill. I don't know what I would do without it. It has given me NO side effects! Very inexpensive and easy to swallow...
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